Age-related hearing loss linked to a protein-producing gene

Age-related hearing loss starts messing with the volume

Communication is key to the human experience. Laughter. Sadness. Anger. Love.

Sound is the way most of us receive life’s narrative. That is, until age-related hearing loss starts messing with the volume. High-pitched voices get harder to understand; phone calls are more difficult to decipher. The stories become muddled. Frustration grows.


There are many reasons why hearing loss and deafness happen. Loud noise, illness, medications such as hormone replacement therapies, all can play a part in a person’s losing the ability to process sounds. Aging, however, remains a leading contender.

“It’s really something that affects every family with older relatives,” says Dolores Madden, Audiologist and Marketing Manager with Hidden Hearing.

It took nine years to complete a University of South Florida formal study, but last month the Universities Global Center for Hearing & Speech Research linked age-related hearing loss to a protein-producing gene in the inner ear. Mutated versions of the gene make the ear unable to translate sounds into nerve impulses interpreted by the brain.

People with a family history of hearing loss now can be tested — and warned — years earlier if that one gene isn’t just right, says the USF study, published in the journal Hearing Research in October.

The research also takes a significant step past what’s already known about how aging changes the inner ear. That includes the understanding that older people should be concerned about damage or death to the tiny hairs inside the ear, which are essential to catching sound waves.

Also, this knowledge might nudge some to take more care with their hearing earlier in life. They might decide to wear headphones while mowing the lawn, or avoid standing too close to speakers at a rock concert. “If you do know, you can take more precautions,” Madden says. ” The earlier someone is diagnosed and treated for hearing loss, the better, for all concerned. Hidden Hearing offer FREE hearing evaluations and it is fast and simple to do.”

If you have any hearing loss issues contact Hidden Hearing online or Freephone 1800 370 000.


Hearing Loss Gene Discovered.

Researchers from the University of South Florida (USF) recently identified a gene related to hearing loss in people. The discovery of a genetic biomarker for age-related hearing loss is nine years in the making.  In particular, the scientists identified a genetic biomarker for presbycuiss and the genetic mutation related to hearing loss can eventually affect a person’s ability to process speech. The researchers from USF and RIT worked with theHouse Ear Institute in finding a gene that creates an important protein in the cochlea, which is the inner ear. The protein, otherwise known as glutamate receptor metabotropic 7 (GRM7), helps convert sound into the code for the nervous system. The brain then utilizes that code for hearing and speech processing purposes.

“This gene is the first genetic biomarker for human age related hearing loss, meaning if you had certain configurations of this gene you would know that you are probably going to lose your hearing faster than someone who might have another configuration,” explained Robert Frisina Jr., a professor at the USF College of Engineering, in a prepared statement.

The study included a DNA analyses by the University of Rochester Medical School and RIT. A total of 687 people participated in the study and completed three hours of examinations regarding their hearing abilities. Testing included observations of speech processing and analyses of genetic material.

The gene appeared to have different results from males and females. The gene ended up having a negative impact for men, but a positive impact for women who reported that they had a better than average hearing in their later years. The differences between males and females relates to a 2006 finding by the Frisina research group that stated that the hormone aldosterone affected hearing capabilities.

The researchers believe that the gene can help people understand how to protect their hearing. They noted that people can prevent hearing loss with little things like avoiding loud noises, particular medications know to cause hearing damage and wearing ear protection. The scientists now understood that presbycusis is caused by a number of different genetic and environmental factors.

“Age-related hearing loss is a very prevalent problem in our society. It costs billions of dollars every year to manage and deal with it. It’s right up there with heart disease and arthritis as far as being one of the top three chronic medical conditions of the aged,” noted Robert Frisina Jr., who also helped found the Global Center for Hearing and Speech Research, in the statement.

If you have any questions about hearing loss contact Hidden Hearing.

Source: Connie K. Ho for – Your Universe Online